Cisplatin

cis-Diamminedichloroplatinum(II)

CAS Number:15663-27-1

Structure Cisplatin

Formula: [Pt(NH3)2Cl2]

Monographs: USP, Ph. Eur., JP *

Drug Master File: available on request

* Monographs are available on request

Chemical Properties

Appearance:

  • Form: Powder
  • Color: Yellow

Odor: Odorless

pH-value at 20 °C (68 °F): 5-7

Change in condition

  • Boiling point/Boiling range: Undetermined.

Flash point: Not applicable.

Flammability (solid, gaseous): Undetermined.

Ignition temperature:

  • Decomposition temperature: >285 °C (>545 °F)

Danger of explosion: Product does not present an explosion hazard.

Vapor pressure: Not applicable.

Density at 20 °C (68 °F): 3.7 g/cm³ (30.877 lbs/gal)

Bulk density at 20 °C (68 °F): 850 kg/m³

Solubility in / Miscibility with water at 20 °C (68 °F): 2.5 g/l

Handling Information

  • Wear protective equipment. Keep unprotected persons away.
  • Work only in fume cabinet.
  • Prevent formation of dust.
  • Store under lock and key and with access restricted to technical experts or their assistants only.
  • Ensure good ventilation/exhaustion at the workplace.
  • Open and handle receptacle with care.

Storage Information

Requirements to be met by storerooms and receptacles:

  • Corrosive action on metals.
  • Store in dry conditions.
  • Store in a cool location.

Information about storage in one common storage facility:

  • Store away from flammable substances.
  • Store away from foodstuffs.

Further information about storage conditions:

  • Protect from exposure to the light.
  • Keep receptacle tightly sealed.

Risk & Safety Information

Classification of the substance or mixture

  • Acute Tox. 2 H300 Fatal if swallowed.
  • Acute Tox. 3 H331 Toxic if inhaled.
  • Resp. Sens. 1 H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled.
  • Muta. 1B H340 May cause genetic defects.
  • Carc. 1B H350 May cause cancer.
  • Met. Corr.1 H290 May be corrosive to metals.
  • Eye Irrit. 2A H319 Causes serious eye irritation.
  • Skin Sens. 1 H317 May cause an allergic skin reaction.
  • STOT SE 3 H335 May cause respiratory irritation.

Classification according to Directive 67/548/EEC or Directive 1999/45/EC

  • Toxic
  • May cause cancer. May cause heritable genetic damage. Toxic by inhalation and if swallowed.
  • Irritant
  • Irritating to eyes and respiratory system. May cause sensitisation by inhalation and skin contact.
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