Oxaliplatin

R,R-1,2-Diaminocyclohexane)oxalatoplatinum(II)

CAS Number: 61825-94-3

Structure Oxaliplatin

Formula: [Pt((R,R)-dach)(ox)]

Monographs: USP, Ph. Eur., JP *

Drug Master File: available on request

* Monographs are available on request

Chemical Properties

Appearance:

  • Form: Crystalline
  • Colour: White

Odour: Odourless

pH-value: Undetermined.

Change in condition

  • Melting point/Melting range: Undetermined.
  • Boiling point/Boiling range: Not applicable.

Flash point: Not applicable.

Flammability (solid, gaseous): Undetermined.

Danger of explosion: Product does not present an explosion hazard.

Density: Not determined.

Solubility in / Miscibility with water at 20 °C: 7.9 g/l

Handling Information

  • Wear protective equipment. Keep unprotected persons away.
  • Work only in fume cupboard.
  • Ensure good ventilation/exhaustion at the workplace.
  • Waste air is to be released into the atmosphere only via suitable separators.
  • Air of exhaustion lead not back to the working room.
  • Store under lock and key and with access restricted to technical experts or their assistants only.
  • Open and handle receptacle with care.
  • Prevent formation of dust.

Information about fire - and explosion protection:

  • Flammable.
  • Formation of toxic gases is possible during heating or in case of fire.
  • Keep respiratory protective device available.

Storage Information

Requirements to be met by storerooms and receptacles:

  • Store only in the original receptacle.
  • Corrosive action on metals.

Information about storage in one common storage facility:

  • Store away from foodstuffs.
  • Store away from flammable substances.

Further information about storage conditions:

  • Store in dry conditions.
  • Protect from exposure to the light.
  • Store under lock and key and with access restricted to technical experts or their assistants only.
  • Keep container tightly sealed.

Risk & Safety Information

Classification according to Regulation (EC) No 1272/2008

  • Acute Tox. 3 H301 Toxic if swallowed.
  • Acute Tox. 3 H311 Toxic in contact with skin.
  • Acute Tox. 3 H331 Toxic if inhaled.
  • Muta. 1B H340 May cause genetic defects.
  • Carc. 1A H350 May cause cancer.
  • Met. Corr.1 H290 May be corrosive to metals.
  • Skin Irrit. 2 H315 Causes skin irritation.
  • Eye Irrit. 2 H319 Causes serious eye irritation.
  • STOT SE 3 H335 May cause respiratory irritation.

Classification according to Directive 67/548/EEC or Directive 1999/45/EC

T; Toxic

R45-46-23/24/25: May cause cancer. May cause heritable genetic damage. Toxic by inhalation, in contact with skin and if swallowed.

Xi; Irritant

R36/37/38: Irritating to eyes, respiratory system and skin.

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