Bendamustin

4-[5-[Bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl] butanoic acid, hydrochloride monohydrate

CAS Number:16506-27-7

Structure Bendamustin

Formula: C16H21Cl2N3O2

Monographs: USP, Ph. Eur., JP *

Drug Master File: available on request

* Monographs are available on request

Chemical Properties

Appearance:

  • Form: Solid
  • Color: White

Odor: Odorless

Change in condition
Boiling point/Boiling range: Not applicable.

Flash point: Not applicable.

Flammability (solid, gaseous): Undetermined.

Ignition temperature:

  • Decomposition temperature: ≈ 240 °C (≈ 464 °F)

Danger of explosion: Product does not present an explosion hazard.

Density: Not determined.
Bulk density at 20 °C (68 °F): ≈ 1.0 kg/m³

Solubility in / Miscibility with water at 20 °C (68 °F): 12.5 g/l

Handling Information

  • Wear protective equipment. Keep unprotected persons away.
  • Work only in fume cabinet.
  • Prevent formation of dust.
  • Only accessible to qualified persons.
  • Open and handle receptacle with care.
  • The usual precautionary measures for handling chemicals should be followed.

Information about protection against explosions and fires:

  • Material is combustible.
  • Keep ignition sources away - Do not smoke.

Storage Information

Requirements to be met by storerooms and receptacles:

  • Store only in the original receptacle.
  • Store in dry conditions.

Information about storage in one common storage facility:

  • Do not store with materials which release oxygen.
  • Store away from flammable substances.
  • Store away from foodstuffs.

Further information about storage conditions:

  • Protect from exposure to the light.
  • Store under lock and key and with access restricted to technical experts or their assistants only.

Recommended storage temperature: < 25 °C

Risk & Safety Information

Classification of the substance or mixture

  • Acute Tox. 2 H300 Fatal if swallowed.
  • Muta. 1B H340 May cause genetic defects.
  • Carc. 1A H350 May cause cancer.
  • Repr. 1B H360 May damage fertility or the unborn child.
  • Eye Irrit. 2A H319 Causes serious eye irritation.

Classification according to Directive 67/548/EEC or Directive 1999/45/EC

  • Toxic
  • May cause cancer. May cause heritable genetic damage. May cause harm to the unborn child. Toxic if swallowed.
  • Irritant
  • Irritating to eyes.
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