Dacarbazine

5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide

CAS Number:4342-03-4

Structure Dacarbazin

Formula: C6H10N6O

Monographs: USP, Ph. Eur., JP *

Drug Master File: available on request

* Monographs are available on request

Chemical Properties

Appearance:

  • Form: Solid
  • Colour: Yellow, Green

Odour: Odourless

Change in condition

  • Melting point/Melting range: 212-215 °C
  • Boiling point/Boiling range: Undetermined.

Flash point: Not applicable.

Danger of explosion: Product does not present an explosion hazard.

Vapour pressure: Undetermined.

Density:

  • Bulk density at 20 °C: 650 kg/m³

Solubility in / Miscibility with water: Slightly soluble.

Handling Information

  • Wear protective equipment. Keep unprotected persons away.
  • Work only in fume cupboard.
  • Open and handle receptacle with care.
  • Prevent formation of dust.
  • Store under lock and key and with access restricted to technical experts or their assistants only.

Storage Information

Requirements to be met by storerooms and receptacles:

  • Store in a cool location.
  • Store in dry conditions.

Information about storage in one common storage facility:

  • Store away from flammable substances.
  • Store away from foodstuffs.

Further information about storage conditions:

  • Keep container tightly sealed.
  • Protect from exposure to the light.

Recommended storage temperature: < 5 °C

Risk & Safety Information

Classification according to Regulation (EC) No 1272/2008

  • Muta. 1B H340 May cause genetic defects.
  • Carc. 1A H350 May cause cancer.
  • Repr. 2 H361d Suspected of damaging the unborn child.
  • Acute Tox. 4 H302 Harmful if swallowed.
  • Acute Tox. 4 H312 Harmful in contact with skin.
  • Acute Tox. 4 H332 Harmful if inhaled.
  • Skin Irrit. 2 H315 Causes skin irritation.
  • Eye Irrit. 2 H319 Causes serious eye irritation.
  • STOT SE 3 H335 May cause respiratory irritation.

Classification according to Directive 67/548/EEC or Directive 1999/45/EC

T; Toxic

R45-46: May cause cancer. May cause heritable genetic damage.

Xn; Harmful

R20/21/22-63: Harmful by inhalation, in contact with skin and if swallowed. Possible risk of harm to the unborn child.

Xi; Irritant

R36/37/38: Irritating to eyes, respiratory system and skin.

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