CAS Number: 52-24-4

Structure Thiotepa

Chemical formula: C6H12N3PS

Monographs: USP, Ph. Eur., JP *

Drug Master File: available on request

* Monographs are available on request

Chemical Properties


  • Form: Powder
  • Color: White

Odor: Recognizable

pH-value (10 g/l) at 20 °C (68 °F): 5-7.5

Change in condition

  • Melting point/Melting range: 52-57 °C (126-135 °F)
  • Boiling point/Boiling range: Undetermined.

Flash point: Not applicable.

Flammability (solid, gaseous): Undetermined.

Danger of explosion: Product does not present an explosion hazard.

Vapor pressure: Undetermined.


  • Bulk density: Not determined.

Solubility in / Miscibility with water at 20 °C (68 °F): 190 g/l

Handling Information

  • Wear protective equipment. Keep unprotected persons away.
  • Work only in fume cabinet.
  • Prevent formation of dust.
  • Store under lock and key and with access restricted to technical experts or their assistants only.
  • Ensure good ventilation/exhaustion at the workplace.
  • Open and handle receptacle with care.

Information about protection against explosions and fires:

  • Keep respiratory protective device available.

Storage Information

Requirements to be met by storerooms and receptacles:

  • Store in dry conditions.
  • Store in a cool location.

Information about storage in one common storage facility:

  • Store away from flammable substances.
  • Store away from foodstuffs.

Further information about storage conditions:

  • Protect from exposure to the light.
  • Keep receptacle tightly sealed.

Recommended storage temperature: < 5 °C

Risk & Safety Information

Classification of the substance or mixture

  • Acute Tox. 2 H300 Fatal if swallowed.
  • Acute Tox. 1 H310 Fatal in contact with skin.
  • Acute Tox. 1 H330 Fatal if inhaled.
  • Resp. Sens. 1 H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled.
  • Muta. 1B H340 May cause genetic defects.
  • Carc. 1A H350 May cause cancer.
  • Repr. 1B H360 May damage fertility or the unborn child.
  • Skin Irrit. 2 H315 Causes skin irritation.
  • Eye Irrit. 2A H319 Causes serious eye irritation.
  • Skin Sens. 1 H317 May cause an allergic skin reaction.
  • STOT SE 3 H335 May cause respiratory irritation.
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