Article in Maîtrise Orthopédique: "PMMA Bone Cement: What is the role of local antibiotics?"

The number of prosthesis-related infections is rising as a consequence of the growing numbers of arthroplasty procedures on often multi-morbid patients. Prevention and treatment of this feared complication is also becoming increasingly complicated and cost-intensive due to the spread of antibiotic-resistant pathogens.

An article recently published in Maitrise Orthopédique during the EFORT congress 2016 in Geneva, Switzerland, provides an overview on why, how and when to use different antibiotic loaded bone cements in the prevention of biofilm formation and support of therapy of prosthetic joint infections in orthopaedic surgery.

The articles focuses on important questions such as:

  • What is the function of single antibiotic (gentamicin)-loaded cements and combinations with additional antibiotics in prophylaxis and treatment of joint infections in the context of current surgical practice and in context of the microbial pathomechanisms?
  • Which antimicrobial efficacy and potential clinical benefit can be expected based on the available evidence and in the context of the high PJI treatment costs?
  • Does the use of antibiotic-loaded bone cement increase the risk of antimicrobial resistance development?