The detection of pathogens, especially in biofilm, which cause PJI is a big challenge. In revision procedures it is difficult to distinguish between aseptic loosening or septic loosening caused by a low-grade infection.
Sampling errors and inadequate sample transport frequently cause false-positive cultures. Incorrect PJI detection may lead to misjudgement in patient-targeted treatments, which bears a risk of complications and extra costs for the hospital. Increasing sensitivity and specificity with anti-biofilm procedures, as with microDTTect, can save personnel and financial resources.