Periprosthetic joint infections (PJI) are one of the most severe complications within endoprosthetic surgery. The PJI-risk is up to 2% in primary procedures and raises to approx. 5% in revision surgery.

Co-morbidities of the patient significantly influence the risk for an infection and should therefore be considered when choosing the optimal treatment algorithm. Dual loaded antibiotic bone cements offer a broad effectiveness against the pathogens commonly causing an infection and prevent periprosthetic joint infections.